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Transworld Research Network 37/661 (2), Fort P.O., Trivandrum-695 023, Kerala, India TRANSWORLD RESEARCH NETWORK Nanostructured Materials…
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128 Margarethe Hofmann-Amtenbrink et al. Screw Teflon tube Figure 3. Layout of the reactor for coating SPIONs. a Jo Figure 4. Structure of…
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Superparamagnetic nanoparticles for biomedical applications 129 in the normal liquid phase. Such equipment allows for a semi automated…
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130 Margarethe Hofmann-Amtenbrink et al. dysprosium predominantly shortens the transverse relaxation time T,. The large magnetic moment of…
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Superparamagnetic nanoparticles for biomedical applications 131 this study, MAC-1 expressing chinese hamster ovary (CHO) cells, expressing…
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132 Margarethe Hofmann-Amtenbrink et al. 3.2.1. Drug delivery The use of magnetic particles in the treatment of cancer is less focused on…
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Superparamagnetic nanoparticles for biomedical applications 133 gradients. Therefore, SPIONs have been developed for therapy of joint…
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134 Margarethe Hofmann-Amtenbrink et al. detected with special iron stains using Prussian Blue (Fe3+) and Turnbulls (Fe2+). SPION up-take…
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Superparamagnetic nanoparticles for biomedical applications 135 Figure 5. SPIONs labeled with Cy3.5 taken up by cells (microglia) can be…
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136 Margarethe Hofmann-Amtenbrink et al. and 120 hours after injection (Fig. 7 and Fig. 8). Results demonstrated good biocompatibility of…
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Superparamagnetic nanoparticles for biomedical applications 137 more local concentration of SPION in the tissue if extracorporal magnets…
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120 Margarethe Hofmann-Amtenbrink et al. Nanoparticles used in biomedical applications include liposomes, polymeric micelles, block ionomer…
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138 Margarethe Hofmann-Amtenbrink et al. 3.2.2. Gene transfection A large number of disorders can be explained or understood with of more…
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Superparamagnetic nanoparticles for biomedical applications 139 principle, transfection coding for green fluorescent protein (pEGFP-C2…
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140 Margarethe Hofmann-Amtenbrink et al. fold in synoviocytes using PEI-SPION. Increase of transfection in controls was considerably less…
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Superparamagnetic nanoparticles for biomedical applications 141 fluid. It was attributed to the positive electric charges of the DNA…
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142 Margarethe Hofmann-Amtenbrink et al. Figure 9. SPION Particles derivatized with nucleus targeting peptides at the surface of nucleus.…
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Superparamagnetic nanoparticles for biomedical applications 143 For the hyperthermia treatment, magnetite cationic liposomes [46] or…
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144 Margarethe Hofmann-Amtenbrink et al. result show that in vitro, alternating magnetic fields induced a high temperature increase to over…
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Superparamagnetic nanoparticles for biomedical applications 145 3.3.2. Tissue soldering Simplification and optimization of vascular bypass…
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146 Margarethe Hofmann-Amtenbrink et al. To investigate how functionalized SPIONs interact with cell organelles, we covalently bound…
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Superparamagnetic nanoparticles for biomedical applications 147 4. 5. 11. 12. 13. 14. 15. 16. 17. 18. Duncan R, Spreafico F. “Polymer…
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Superparamagnetic nanoparticles for biomedical applications 121 and subsequent separation in a magnetic field gradient for diagnostic…
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148 Margarethe Hofmann-Amtenbrink et al. 19. A. Petri-Fink et al., “Development of functionalized superparamagnetic iron oxide…
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Superparamagnetic nanoparticles for biomedical applications 149 37. 38. 39. 40. 41. 42. 43. 44. 45. . M. Yanase et al. “Intracellular…
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122 Margarethe Hofmann-Amtenbrink et al. paramagnetic materials showing small and positive susceptibility, and ferromagnetic materials…
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Superparamagnetic nanoparticles for biomedical applications 123 nanosized crystals have to be reoriented very quickly depending on the…
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124 Margarethe Hofmann-Amtenbrink et al. F,(2)=r39(M@)BO) (2) where r,, is the radius of the magnetic part of the particle, M the…
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Superparamagnetic nanoparticles for biomedical applications 125 LE+11 200 MHz LE+10 | 20 MHz — 1.E+09 | ° ° ® 1£+08 | u 2 MHz —£ 1E+07 | =…
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126 Margarethe Hofmann-Amtenbrink et al. those coated with polyethylenimine (PEI-SPION). While uncoated SPIONs agglomerate immediately in…
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Superparamagnetic nanoparticles for biomedical applications 127 stream for MRI applications (blood-pool contrast agent). An overview on…